Selank: research summary
For laboratory research use only. Not for human or veterinary use. This page summarises published literature. It gives no advice on use.
What the literature covers
Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is an analogue of the immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), extended with Pro-Gly-Pro at the C-terminus for stability. It was developed at the Institute of Molecular Genetics in Moscow.
Published research includes gene-expression studies in IMR-32 neuroblastoma cells and rodent behavioural-conditioning studies. As a proline-rich regulatory oligopeptide, it has also been compared with related peptides in haemostasis assays.
Selank has a molecular weight of about 751.9 g/mol (C33H57N11O9). It is water-soluble and is usually supplied as an acetate salt.
Key facts
| Selank | Semax | |
|---|---|---|
| CAS | 129954-34-3 | 80714-61-0 |
| Formula | C33H57N11O9 | C37H51N9O10S |
| Molecular weight (g/mol) | 751.9 | 813.9 |
Source: PubChem CID 11765600.
Selank compared with Semax
Selank and Semax come from the same Moscow institute and both end in the stabilising Pro-Gly-Pro motif. Selank extends tuftsin, a fragment of an immunoglobulin heavy chain. Semax extends ACTH(4-7), a fragment of adrenocorticotropic hormone.
Full side-by-side: Selank vs Semax
Frequently asked questions
- What is Selank derived from?
- Tuftsin (Thr-Lys-Pro-Arg), with a Pro-Gly-Pro extension at the C-terminus.
- How is Selank related to Semax?
- Both are Pro-Gly-Pro-extended analogues from the same research institute. Selank is based on tuftsin and Semax on ACTH(4-7).
- What is the molecular weight of Selank?
- About 751.9 g/mol (C33H57N11O9, PubChem CID 11765600).
Published literature cited
- Filatova E, Kasian A, Kolomin T, Rybalkina E, Alieva A, Andreeva L, Limborska S, Myasoedov N, Pavlova G, Slominsky P, Shadrina M. (2017). GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front Pharmacol. PMID 28293190 · doi:10.3389/fphar.2017.00089
- Liapina LA, Pastorova VE, Obergan TIu, Samonina GE, Ashmarin IP, Miasoedov NF. (2006). [Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]. Izv Akad Nauk Ser Biol. PMID 16634437 · doi:10.1134/s1062359006020099
- Kozlovskii II, Danchev ND. (2003). The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. PMID 14552529 · doi:10.1023/a:1024444321191
Every citation was looked up by PMID in Europe PMC (MEDLINE) on 2026-10-14 and its title matched. Citation means the paper exists and is relevant to the compound. It does not mean the paper supports any use.