What is the molecular weight of semaglutide?
The molecular weight of Semaglutide is 4114.0 g/mol on the registry record used for identity. The molecular formula is C187H291N45O59. CAS Registry Number 910463-68-2. PubChem CID 56843331. It is classed as a peptide (lipidated). Synonyms include GLP-1 analogue with C18 fatty diacid side chain.
Mass. The expected average mass for identity confirmation is 4114.0 g/mol.
Formula. C187H291N45O59.
Analytical note. Sable's release specification is ≥99% by HPLC with identity confirmed against the expected mass (quality page). Research use only. Not a medicine. Not for human or veterinary use.
Sources
Semaglutide: reference facts
7 Semaglutide values, each linked to its public source; see the Semaglutide reference page.
| Synonyms | GLP-1 analogue with C18 fatty diacid side chain (pubchem.ncbi.nlm.nih.gov) |
|---|---|
| Compound class | peptide (lipidated) (pubchem.ncbi.nlm.nih.gov) |
| CAS Registry Number | 910463-68-2 (pubchem.ncbi.nlm.nih.gov) |
| Molecular formula | C187H291N45O59 (pubchem.ncbi.nlm.nih.gov) |
| Molecular weight | 4114.0 g/mol (pubchem.ncbi.nlm.nih.gov) |
| PubChem CID | 56843331 (pubchem.ncbi.nlm.nih.gov) |
| Storage (lyophilised) | -20 °C, dry, protected from light (sigmaaldrich.com) |
Sizes and prices at Sable
| Vial | Price | Per mg | UK same-size check (2026-10-16) |
|---|---|---|---|
| 1 mg | £21.49 | £21.49 | no same-size match |
| 2 mg | £34.99 | £17.50 | no same-size match |
| 5 mg | £28.98 | £5.80 | no same-size match |
| 8 mg | £66.49 | £8.31 | no same-size match |
| 10 mg | £38.98 | £3.90 | no same-size match |
| 20 mg | £64.98 | £3.25 | no same-size match |
| 30 mg | £84.98 | £2.83 | no same-size match |
Multi-vial pricing on the same item: 3+ vials 10% off, 5+ vials 15% off, 10+ vials 20% off. Every lot has a certificate of analysis: CoA library.
Typical analytical method
| HPLC column | C18 reversed-phase (300 A pore, C4/C8 suitable for large/lipidated) |
|---|---|
| Mobile phase | A: water + 0.1% TFA; B: acetonitrile + 0.1% TFA; linear gradient (e.g. 5-65% B over 20-30 min) |
| Detection | 214-220 nm (peptide bond) |
General literature method. The lot CoA records the method actually used. How to read an HPLC chromatogram.
Related questions
Lyophilised storage on file: Semaglutide
From the Sable storage reference (lyophilised material only; temperature, light, moisture). Literature basis is linked per row. See peptide storage.
| Compound | Lyophilised storage | Light / notes |
|---|---|---|
| Semaglutide | -20 C long term (-80 C acceptable), sealed and desiccated; 2-8 C for weeks | protect from light; no specific sequence liabilities identified from sequence data on file (source) |
Typical analytical method: Semaglutide
Reference HPLC and MS conditions from the Sable analytical-methods file; a lot's CoA states the method actually used. See how to read a CoA.
| Compound | HPLC column / detection | MS / expected ion |
|---|---|---|
| Semaglutide | C18 reversed-phase (300 A pore, C4/C8 suitable for large/lipidated); 214-220 nm (peptide bond) | ESI-MS (positive mode); LC-MS for identity; [M+3H]3+ ~1372.3; [M+4H]4+ ~1029.5; [M+5H]5+ ~823.8; [M+6H]6+ ~686.7 |
Research use only. Not a medicine. Not for human or veterinary use.