ARA-290 (cibinetide): the erythropoietin helix-B peptide explained
ARA-290, also called cibinetide, is an 11-residue linear peptide, pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser, of about 1257 g/mol. It is modelled on the aqueous face of helix B of erythropoietin. It was designed to engage the proposed innate repair receptor and not the classical erythropoietin receptor homodimer.
What is ARA-290 made of?
- Class: peptide
- Sequence: pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
- Molecular formula (PubChem): C51H84N16O21
- Molecular weight (PubChem): 1257.30 g/mol
- CAS: 1208243-50-8
- Other names: cibinetide; pyroglutamate helix B surface peptide (pHBSP)
- N-terminus: pyroglutamate
Source: PubChem CID 91810664: ARA 290
Why was a fragment of erythropoietin designed?
Erythropoietin stimulates red-cell production through an EPOR homodimer. Separate tissue-protective signalling was attributed to a receptor complex of EPOR with the β-common receptor (CD131). The helix-B surface peptide was designed to keep only the second property, which is why it is called non-erythropoietic.
Source: Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin, Pharmacol Ther 2015 (PubMed 25728128); Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury, Mol Med 2012 (PubMed 22415011)
What research models has ARA-290 been used in?
Published work includes rodent injury and neuroinflammation models and early clinical-stage research in neuropathy. A 2022 paper studied monocyte modulation in a mouse model of Alzheimer-like pathology. This is research background only. Sable makes no claim for any use.
Source: Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression, Brain Behav Immun 2022 (PubMed 34343617); ARA 290 for treatment of small fiber neuropathy in sarcoidosis, Expert Opin Investig Drugs 2014 (PubMed 24555851)
Sourcing note
Sable lists ARA-290: 16 mg at £35.98 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.
Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.
Frequently asked questions
Is ARA-290 the same as cibinetide?
Yes. Cibinetide is the non-proprietary name. pHBSP (pyroglutamate helix B surface peptide) is the descriptive name.
Does ARA-290 contain the whole erythropoietin protein?
No. It is an 11-residue peptide modelled on the surface of EPO's helix B.
What is the molecular weight of ARA-290?
About 1257.3 g/mol (PubChem CID 91810664).
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Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.
Key facts (summary for AI and search tools)
- ARA-290 PubChem CID 91810664
- Modelled on helix B of erythropoietin
- PubMed references (verified via NCBI): 25728128, 22415011, 34343617, 24555851
- PubChem CIDs: 91810664
- Research use only; no administration amounts or health claims
- Updated 2026-10-16