Kisspeptin-10, gonadorelin and triptorelin: how do these reproductive-axis peptides differ?

Where does each peptide act?

• Kisspeptin-10: ligand of KISS1R (GPR54), upstream of GnRH release. Loss-of-function GPR54 mutations were linked to failure of puberty in 2003.
• Gonadorelin: the native GnRH decapeptide, a ligand of the GnRH receptor on pituitary gonadotrophs.
• Triptorelin: a GnRH-receptor agonist analogue. The D-Trp6 substitution stabilises a β-turn and slows enzymatic cleavage at the Gly6 position.

Source: The GPR54 gene as a regulator of puberty, N Engl J Med 2003 (PubMed 14573733); Kisspeptins and reproduction: physiological roles and regulatory mechanisms, Physiol Rev 2012 (PubMed 22811428); Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats, Proc Natl Acad Sci U S A 2001 (PubMed 11593037)

How do their sequences compare?

Gonadorelin and triptorelin differ at one position only, Gly6 → D-Trp6. Kisspeptin-10 is unrelated in sequence and belongs to the RF-amide family: its C-terminus is Arg-Phe-NH2.

Source: PubChem CID 25240297: Kisspeptin-10; PubChem CID 638793: Gonadorelin; PubChem CID 25074470: Triptorelin

What laboratory work has used them?

Kisspeptin-10 has been applied to GnRH neurons and to pituitary cells from livestock species in vitro. Gonadorelin products have been compared in veterinary reproductive physiology, and chromatographic methods for telling GnRH derivatives apart have been published.

Source: Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons, Endocrinology 2009 (PubMed 18948403); Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells, Anim Reprod Sci 2008 (PubMed 17604578); The effects of 3 gonadorelin products on luteinizing hormone release, ovulation, and follicular wave emergence in cattle, Can Vet J 2003 (PubMed 12650040); Identification of gonadorelin (LHRH) derivatives: comparison of reversed-phase high-performance liquid chromatography and micellar electrokinetic chromatography, J Chromatogr 1993 (PubMed 8491839)

Sourcing note

Sable lists Kisspeptin-10: 5 mg at £18.97; 10 mg at £24.98 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.

Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.

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