Glossary

Aspartimide formation

Aspartimide formation is a side reaction in Fmoc peptide synthesis in which an aspartic acid side chain cyclises onto the backbone amide nitrogen, forming a five-membered succinimide ring. It is favoured by exposure to base and sequences such as Asp-Gly. Ring opening yields alpha- and beta-aspartyl peptides and racemised products, complicating purification.

Source: pmc.ncbi.nlm.nih.gov

Back to glossary A–Z

All Sable Peptides products are supplied for laboratory research use only. Not for consumption.