What is the amino acid sequence of triptorelin?
Triptorelin is a research peptide whose amino acid sequence is on the public registry record. The published sequence is pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2. Its molecular formula is C64H82N18O13. Its molecular weight is 1311.4 g/mol. The CAS Registry Number is 57773-63-4. PubChem CID 25074470 indexes the structure.
Sequence. pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Class. peptide.
Formula. C64H82N18O13.
Mass. 1311.4 g/mol.
Analytical note. Identity confirmation by mass spectrometry uses the mass calculated from the formula. Sable's release specification is ≥99% by HPLC with identity confirmed against the expected mass (quality page). Research use only. Not a medicine. Not for human or veterinary use.
Sources
Triptorelin: reference facts
8 Triptorelin values, each linked to its public source; see the Triptorelin reference page.
| Synonyms | [D-Trp6]-LHRH (pubchem.ncbi.nlm.nih.gov) |
|---|---|
| Compound class | peptide (pubchem.ncbi.nlm.nih.gov) |
| CAS Registry Number | 57773-63-4 (pubchem.ncbi.nlm.nih.gov) |
| Sequence | pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 (pubchem.ncbi.nlm.nih.gov) |
| Molecular formula | C64H82N18O13 (pubchem.ncbi.nlm.nih.gov) |
| Molecular weight | 1311.4 g/mol (pubchem.ncbi.nlm.nih.gov) |
| PubChem CID | 25074470 (pubchem.ncbi.nlm.nih.gov) |
| Storage (lyophilised) | -20 °C, dry, protected from light (sigmaaldrich.com) |
Calculated sequence properties
Computed from the listed sequence. See the methodology.
| Length | 10 residues |
|---|---|
| Theoretical pI | 11.3 (calculated from sequence) |
| Net charge at pH 7 | 1.24 (calculated) |
| Extinction coefficient, 280 nm | 12490 M⁻¹cm⁻¹ (calculated) |
| Structure note | N-terminal pyroglutamate (Glu side chain and N-terminus not ionisable; counted as E for composition only); 1 D-residue(s); same composition values as L-forms |
Sizes and prices at Sable
| Vial | Price | Per mg | UK same-size check (2026-10-16) |
|---|---|---|---|
| 2 mg | £17.98 | £8.99 | no same-size match |
| 5 mg | £25.99 | £5.20 | no same-size match |
Multi-vial pricing on the same item: 3+ vials 10% off, 5+ vials 15% off, 10+ vials 20% off. Every lot has a certificate of analysis: CoA library.
Typical analytical method
| HPLC column | C18 reversed-phase (100-120 A pore) |
|---|---|
| Mobile phase | A: water + 0.1% TFA; B: acetonitrile + 0.1% TFA; linear gradient (e.g. 5-65% B over 20-30 min) |
| Detection | 214-220 nm (peptide bond) and 280 nm (Trp/Tyr present) |
General literature method. The lot CoA records the method actually used. How to read an HPLC chromatogram.
Related questions
Lyophilised storage on file: Triptorelin
From the Sable storage reference (lyophilised material only; temperature, light, moisture). Literature basis is linked per row. See peptide storage.
| Compound | Lyophilised storage | Light / notes |
|---|---|---|
| Triptorelin | -20 C long term (-80 C acceptable), sealed and desiccated; 2-8 C for weeks | protect from light; contains Met/Cys/Trp: oxidation-prone; minimise air/headspace exposure (source) |
Typical analytical method: Triptorelin
Reference HPLC and MS conditions from the Sable analytical-methods file; a lot's CoA states the method actually used. See how to read a CoA.
| Compound | HPLC column / detection | MS / expected ion |
|---|---|---|
| Triptorelin | C18 reversed-phase (100-120 A pore); 214-220 nm (peptide bond) and 280 nm (Trp/Tyr present) | ESI-MS (positive mode); LC-MS for identity; [M+1H]1+ ~1312.4; [M+2H]2+ ~656.7; [M+3H]3+ ~438.1 |
Research use only. Not a medicine. Not for human or veterinary use.