What is the amino acid sequence of MOTS-c?
MOTS-c is a research peptide whose amino acid sequence is on the public registry record. The published sequence is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg. Its molecular formula is C101H152N28O22S2. Its molecular weight is 2174.6 g/mol. The CAS Registry Number is 1627580-64-6. PubChem CID 146675088 indexes the structure.
Sequence. Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Class. peptide.
Formula. C101H152N28O22S2.
Mass. 2174.6 g/mol.
Analytical note. Identity confirmation by mass spectrometry uses the mass calculated from the formula. Sable's release specification is ≥99% by HPLC with identity confirmed against the expected mass (quality page). Research use only. Not a medicine. Not for human or veterinary use.
Sources
MOTS-c: reference facts
8 MOTS-c values, each linked to its public source; see the MOTS-c reference page.
| Synonyms | mitochondrial ORF of the 12S rRNA type-c (pubchem.ncbi.nlm.nih.gov) |
|---|---|
| Compound class | peptide (pubchem.ncbi.nlm.nih.gov) |
| CAS Registry Number | 1627580-64-6 (pubchem.ncbi.nlm.nih.gov) |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (pubchem.ncbi.nlm.nih.gov) |
| Molecular formula | C101H152N28O22S2 (pubchem.ncbi.nlm.nih.gov) |
| Molecular weight | 2174.6 g/mol (pubchem.ncbi.nlm.nih.gov) |
| PubChem CID | 146675088 (pubchem.ncbi.nlm.nih.gov) |
| Storage (lyophilised) | -20 °C, dry, protected from light (sigmaaldrich.com) |
Calculated sequence properties
Computed from the listed sequence. See the methodology.
| Length | 16 residues |
|---|---|
| Theoretical pI | 10.64 (calculated from sequence) |
| Net charge at pH 7 | 2.98 (calculated) |
| Extinction coefficient, 280 nm | 8480 M⁻¹cm⁻¹ (calculated) |
Sizes and prices at Sable
| Vial | Price | Per mg | UK same-size check (2026-10-16) |
|---|---|---|---|
| 5 mg | £9.85 | £1.97 | lowest other £19.50 across 1 UK sellers |
| 10 mg | £14.97 | £1.50 | lowest other £14.99 across 17 UK sellers |
| 20 mg | £28.98 | £1.45 | lowest other £35.00 across 3 UK sellers |
| 30 mg | £42.19 | £1.41 | no same-size match |
| 40 mg | £39.97 | £1.00 | lowest other £39.99 across 11 UK sellers |
Multi-vial pricing on the same item: 3+ vials 10% off, 5+ vials 15% off, 10+ vials 20% off. Every lot has a certificate of analysis: CoA library.
Typical analytical method
| HPLC column | C18 reversed-phase (100-120 A pore) |
|---|---|
| Mobile phase | A: water + 0.1% TFA; B: acetonitrile + 0.1% TFA; linear gradient (e.g. 5-65% B over 20-30 min) |
| Detection | 214-220 nm (peptide bond) and 280 nm (Trp/Tyr present) |
General literature method. The lot CoA records the method actually used. How to read an HPLC chromatogram.
Related questions
Lyophilised storage on file: MOTS-c
From the Sable storage reference (lyophilised material only; temperature, light, moisture). Literature basis is linked per row. See peptide storage.
| Compound | Lyophilised storage | Light / notes |
|---|---|---|
| MOTS-c | -20 C long term (-80 C acceptable), sealed and desiccated; 2-8 C for weeks | protect from light; contains Met/Cys/Trp: oxidation-prone; minimise air/headspace exposure (source) |
Typical analytical method: MOTS-c
Reference HPLC and MS conditions from the Sable analytical-methods file; a lot's CoA states the method actually used. See how to read a CoA.
| Compound | HPLC column / detection | MS / expected ion |
|---|---|---|
| MOTS-c | C18 reversed-phase (100-120 A pore); 214-220 nm (peptide bond) and 280 nm (Trp/Tyr present) | ESI-MS (positive mode); LC-MS for identity; [M+1H]1+ ~2175.6; [M+2H]2+ ~1088.3; [M+3H]3+ ~725.9 |
Research use only. Not a medicine. Not for human or veterinary use.