What is the amino acid sequence of gonadorelin?
Gonadorelin is a research peptide whose amino acid sequence is on the public registry record. The published sequence is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Its molecular formula is C55H75N17O13. Its molecular weight is 1182.3 g/mol. The CAS Registry Number is 33515-09-2. PubChem CID 638793 indexes the structure.
Sequence. pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Class. peptide.
Formula. C55H75N17O13.
Mass. 1182.3 g/mol.
Analytical note. Identity confirmation by mass spectrometry uses the mass calculated from the formula. Sable's release specification is ≥99% by HPLC with identity confirmed against the expected mass (quality page). Research use only. Not a medicine. Not for human or veterinary use.
Sources
Gonadorelin: reference facts
8 Gonadorelin values, each linked to its public source; see the Gonadorelin reference page.
| Synonyms | GnRH; LHRH; luteinising hormone-releasing hormone (pubchem.ncbi.nlm.nih.gov) |
|---|---|
| Compound class | peptide (pubchem.ncbi.nlm.nih.gov) |
| CAS Registry Number | 33515-09-2 (pubchem.ncbi.nlm.nih.gov) |
| Sequence | pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (pubchem.ncbi.nlm.nih.gov) |
| Molecular formula | C55H75N17O13 (pubchem.ncbi.nlm.nih.gov) |
| Molecular weight | 1182.3 g/mol (pubchem.ncbi.nlm.nih.gov) |
| PubChem CID | 638793 (pubchem.ncbi.nlm.nih.gov) |
| Storage (lyophilised) | -20 °C, dry, protected from light (sigmaaldrich.com) |
Calculated sequence properties
Computed from the listed sequence. See the methodology.
| Length | 10 residues |
|---|---|
| Theoretical pI | 11.3 (calculated from sequence) |
| Net charge at pH 7 | 1.24 (calculated) |
| Extinction coefficient, 280 nm | 6990 M⁻¹cm⁻¹ (calculated) |
| Structure note | N-terminal pyroglutamate (Glu side chain and N-terminus not ionisable; counted as E for composition only) |
Sizes and prices at Sable
| Vial | Price | Per mg | UK same-size check (2026-10-16) |
|---|---|---|---|
| 5 mg | £16.99 | £3.40 | no same-size match |
| 10 mg | £21.49 | £2.15 | no same-size match |
Multi-vial pricing on the same item: 3+ vials 10% off, 5+ vials 15% off, 10+ vials 20% off. Every lot has a certificate of analysis: CoA library.
Typical analytical method
| HPLC column | C18 reversed-phase (100-120 A pore) |
|---|---|
| Mobile phase | A: water + 0.1% TFA; B: acetonitrile + 0.1% TFA; linear gradient (e.g. 5-65% B over 20-30 min) |
| Detection | 214-220 nm (peptide bond) and 280 nm (Trp/Tyr present) |
General literature method. The lot CoA records the method actually used. How to read an HPLC chromatogram.
Lyophilised storage on file: Gonadorelin
From the Sable storage reference (lyophilised material only; temperature, light, moisture). Literature basis is linked per row. See peptide storage.
| Compound | Lyophilised storage | Light / notes |
|---|---|---|
| Gonadorelin | -20 C long term (-80 C acceptable), sealed and desiccated; 2-8 C for weeks | protect from light; contains Met/Cys/Trp: oxidation-prone; minimise air/headspace exposure (source) |
Typical analytical method: Gonadorelin
Reference HPLC and MS conditions from the Sable analytical-methods file; a lot's CoA states the method actually used. See how to read a CoA.
| Compound | HPLC column / detection | MS / expected ion |
|---|---|---|
| Gonadorelin | C18 reversed-phase (100-120 A pore); 214-220 nm (peptide bond) and 280 nm (Trp/Tyr present) | ESI-MS (positive mode); LC-MS for identity; [M+1H]1+ ~1183.3; [M+2H]2+ ~592.2; [M+3H]3+ ~395.1 |
Research use only. Not a medicine. Not for human or veterinary use.