Sable · Question
What is the difference between MOTS-c and P21?
MOTS-c is a 16-residue mitochondrial-derived peptide encoded in the 12S rRNA region, described in 2015 and studied in cellular metabolism research (peptide, MW about 2174.6 g/mol).
Research use only. Not for human consumption. No health claims.
Last verified 2026-10-10
What is the difference between MOTS-c and P21?
MOTS-c is a 16-residue mitochondrial-derived peptide encoded in the 12S rRNA region, described in 2015 and studied in cellular metabolism research (peptide, MW about 2174.6 g/mol).
Which is heavier, MOTS-c or P21?
MOTS-c has a molecular weight of about 2174.6 g/mol and P21 about 578.7 g/mol (PubChem), so MOTS-c is heavier by 1,595.9 g/mol, a ratio of 3.76. This means 1 mg of MOTS-c contains 459.9 nmol versus 1,728 nmol for P21.
How many mg of P21 are equimolar to 1 mg of MOTS-c?
1 mg of MOTS-c (MW 2174.6) is 459.9 nmol. The same number of moles of P21 (MW 578.7) weighs 0.2661 mg. Equimolar comparisons matter when testing two compounds side by side in the same assay.
Compare the molecular formulas of MOTS-c and P21
PubChem lists MOTS-c as C101H152N28O22S2 (2174.6 g/mol) and P21 as C27H42N6O8 (578.7 g/mol). MOTS-c is a peptide; P21 is a peptidomimetic. These formulas refer to the parent compounds without salt counter-ions.
A 5 mg vial of MOTS-c equals how many mg of P21 in moles?
5 mg of MOTS-c (MW 2174.6) is 2.299 µmol. The same amount of P21 (MW 578.7) would weigh 1.331 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 10 mg vial of MOTS-c equals how many mg of P21 in moles?
10 mg of MOTS-c (MW 2174.6) is 4.599 µmol. The same amount of P21 (MW 578.7) would weigh 2.661 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 20 mg vial of MOTS-c equals how many mg of P21 in moles?
20 mg of MOTS-c (MW 2174.6) is 9.197 µmol. The same amount of P21 (MW 578.7) would weigh 5.322 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 30 mg vial of MOTS-c equals how many mg of P21 in moles?
30 mg of MOTS-c (MW 2174.6) is 13.796 µmol. The same amount of P21 (MW 578.7) would weigh 7.984 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 40 mg vial of MOTS-c equals how many mg of P21 in moles?
40 mg of MOTS-c (MW 2174.6) is 18.394 µmol. The same amount of P21 (MW 578.7) would weigh 10.645 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 10 mg vial of P21 equals how many mg of MOTS-c in moles?
10 mg of P21 (MW 578.7) is 17.28 µmol. The same amount of MOTS-c (MW 2174.6) would weigh 37.577 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 5 mg vial of P21 equals how many mg of MOTS-c in moles?
5 mg of P21 (MW 578.7) is 8.64 µmol. The same amount of MOTS-c (MW 2174.6) would weigh 18.789 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A CoA for every lot; each vial carries a printed lot number that matches it. Ask with the lot number and we send it.
Cite this
Research use only. Not for consumption. No health claims.
Plain
Sable Peptides. (2026). What is the difference between MOTS-c and P21?. UK Research Peptide Reference. Retrieved 11 October 2026, from https://www.sablepeptides.co.uk/questions/compare/mots-c-vs-p21/#sqa-040049
APA
Sable Peptides. (2026, October 11). *What is the difference between MOTS-c and P21?*. UK Research Peptide Reference. https://www.sablepeptides.co.uk/questions/compare/mots-c-vs-p21/#sqa-040049
BibTeX
@misc{sable_#sqa-040049_2026,
author = {{Sable Peptides}},
title = {{What is the difference between MOTS-c and P21?}},
year = {2026},
howpublished = {\url{https://www.sablepeptides.co.uk/questions/compare/mots-c-vs-p21/#sqa-040049}},
note = {Accessed 11 October 2026. CC BY 4.0}
}Badge
<a href="https://www.sablepeptides.co.uk/ref"><img src="https://www.sablepeptides.co.uk/badge/ref.svg" alt="Data: UK Research Peptide Reference — Sable Peptides" width="220" height="40"></a>
Date modified: 2026-10-10