Sable · Question
What is the difference between FOXO4-DRI and P21?
FOXO4-DRI is a D-retro-inverso peptide designed to interfere with FOXO4-p53 binding, described in a 2017 Cell paper on senescent-cell research in mice (peptide (D-retro-inverso), MW about 5358 g/mol).
Research use only. Not for human consumption. No health claims.
Last verified 2026-10-10
What is the difference between FOXO4-DRI and P21?
FOXO4-DRI is a D-retro-inverso peptide designed to interfere with FOXO4-p53 binding, described in a 2017 Cell paper on senescent-cell research in mice (peptide (D-retro-inverso), MW about 5358 g/mol).
Which is heavier, FOXO4-DRI or P21?
FOXO4-DRI has a molecular weight of about 5358 g/mol and P21 about 578.7 g/mol (PubChem), so FOXO4-DRI is heavier by 4,779.3 g/mol, a ratio of 9.26. This means 1 mg of FOXO4-DRI contains 186.6 nmol versus 1,728 nmol for P21.
How many mg of P21 are equimolar to 1 mg of FOXO4-DRI?
1 mg of FOXO4-DRI (MW 5358) is 186.6 nmol. The same number of moles of P21 (MW 578.7) weighs 0.108 mg. Equimolar comparisons matter when testing two compounds side by side in the same assay.
Compare the molecular formulas of FOXO4-DRI and P21
PubChem lists FOXO4-DRI as C228H388N86O64 (5358 g/mol) and P21 as C27H42N6O8 (578.7 g/mol). FOXO4-DRI is a peptide (D-retro-inverso); P21 is a peptidomimetic. These formulas refer to the parent compounds without salt counter-ions.
A 5 mg vial of FOXO4-DRI equals how many mg of P21 in moles?
5 mg of FOXO4-DRI (MW 5358) is 0.9332 µmol. The same amount of P21 (MW 578.7) would weigh 0.54 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 10 mg vial of FOXO4-DRI equals how many mg of P21 in moles?
10 mg of FOXO4-DRI (MW 5358) is 1.866 µmol. The same amount of P21 (MW 578.7) would weigh 1.08 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 10 mg vial of P21 equals how many mg of FOXO4-DRI in moles?
10 mg of P21 (MW 578.7) is 17.28 µmol. The same amount of FOXO4-DRI (MW 5358) would weigh 92.587 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
A 5 mg vial of P21 equals how many mg of FOXO4-DRI in moles?
5 mg of P21 (MW 578.7) is 8.64 µmol. The same amount of FOXO4-DRI (MW 5358) would weigh 46.293 mg. This equimolar conversion lets two compounds be compared at matched molar amounts in the same experiment.
More questions about foxo4-dri
A CoA for every lot; each vial carries a printed lot number that matches it. Ask with the lot number and we send it.
Cite this
Research use only. Not for consumption. No health claims.
Plain
Sable Peptides. (2026). What is the difference between FOXO4-DRI and P21?. UK Research Peptide Reference. Retrieved 11 October 2026, from https://www.sablepeptides.co.uk/questions/compare/foxo4-dri-vs-p21/#sqa-038839
APA
Sable Peptides. (2026, October 11). *What is the difference between FOXO4-DRI and P21?*. UK Research Peptide Reference. https://www.sablepeptides.co.uk/questions/compare/foxo4-dri-vs-p21/#sqa-038839
BibTeX
@misc{sable_#sqa-038839_2026,
author = {{Sable Peptides}},
title = {{What is the difference between FOXO4-DRI and P21?}},
year = {2026},
howpublished = {\url{https://www.sablepeptides.co.uk/questions/compare/foxo4-dri-vs-p21/#sqa-038839}},
note = {Accessed 11 October 2026. CC BY 4.0}
}Badge
<a href="https://www.sablepeptides.co.uk/ref"><img src="https://www.sablepeptides.co.uk/badge/ref.svg" alt="Data: UK Research Peptide Reference — Sable Peptides" width="220" height="40"></a>
Date modified: 2026-10-10