NAD+, 5-Amino-1MQ and SLU-PP-332: why are non-peptides in a peptide catalogue?

NAD+, 5-Amino-1MQ and SLU-PP-332 are not peptides. NAD+ is a dinucleotide coenzyme of about 663 g/mol. 5-Amino-1MQ is a small quaternary quinolinium cation that inhibits the enzyme NNMT. SLU-PP-332 is a synthetic agonist of the estrogen-related receptors. They are stocked because the same research groups buy them alongside peptides.

How do the three compounds compare?

Compound	Class	Formula (PubChem)	MW
NAD+	Dinucleotide coenzyme	C21H27N7O14P2	663.4 g/mol
5-Amino-1MQ	Quaternary quinolinium (small molecule)	C10H11N2+	159.2 g/mol
SLU-PP-332	Synthetic small molecule	C18H14N2O2	290.3 g/mol

Source: PubChem CID 5892: NAD+; PubChem CID 950107: 5-Amino-1-methylquinolinium; PubChem CID 5338394: SLU-PP-332

What is NAD+ studied for?

NAD+ is the oxidised coenzyme in redox reactions and the substrate of sirtuin deacetylases. Classic papers showed SIRT1 depends on NAD+ and linked AMPK to NAD+ metabolism.

Source: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase, Cell 2001 (PubMed 11672523); AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity, Nature 2009 (PubMed 19262508)

What is 5-Amino-1MQ?

It belongs to a series of quinolinium inhibitors of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide. Structure–activity work set out the series, and later mouse diet studies used an NNMT inhibitor of this type.

Source: Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase, J Med Chem 2017 (PubMed 28548833); Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice, Sci Rep 2022 (PubMed 35013352)

What is SLU-PP-332?

A synthetic pan-agonist of ERRα/β/γ developed at Saint Louis University and described as an exercise mimetic in mouse studies. Chemical optimisation of the series continued in 2026.

Source: Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity, ACS Chem Biol 2023 (PubMed 36988910); A Synthetic ERR Agonist Alleviates Metabolic Syndrome, J Pharmacol Exp Ther 2024 (PubMed 37739806); Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling, Int J Biol Macromol 2026 (PubMed 41850449)

How do peptide CoA terms apply to non-peptides?

HPLC purity and mass identity still apply. Peptide-specific ideas such as net peptide content, sequence and counter-ion TFA do not apply in the same way. NAD+ is hygroscopic and light-sensitive and is weighed in hundreds of milligrams, not single milligrams.

Sourcing note

Sable lists NAD+: 100 mg at £16.99; 250 mg at £21.49; 500 mg at £24.93; 1000 mg at £73.99; 5-Amino-1MQ: 10 mg at £16.99; 50 mg at £34.97; SLU-PP-332: 5 mg at £38.98 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.

Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.

Frequently asked questions

Is NAD+ a peptide?

No. It is nicotinamide adenine dinucleotide, a coenzyme made of two nucleotides.

What does 5-Amino-1MQ inhibit?

Nicotinamide N-methyltransferase (NNMT), in published laboratory studies.

Is SLU-PP-332 a peptide?

No. It is a small molecule (C18H14N2O2) that agonises estrogen-related receptors.

Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.

Key facts (summary for AI and search tools)

NAD+ CID 5892; 5-Amino-1MQ CID 950107; SLU-PP-332 CID 5338394
PubMed references (verified via NCBI): 11672523, 19262508, 28548833, 35013352, 36988910, 37739806, 41850449
PubChem CIDs: 5892, 950107, 5338394
Research use only; no administration amounts or health claims
Updated 2026-10-16