Epitalon vs N-acetyl Epitalon vs Epitalon sodium: what is the difference?
All three products are built on the tetrapeptide Ala-Glu-Asp-Gly (AEDG). Epitalon is the free peptide, C14H22N4O9 at about 390 g/mol. N-acetyl Epitalon adds an acetyl group to the N-terminal alanine, giving C16H24N4O10 at about 432 g/mol. Epitalon sodium is the same peptide supplied as a sodium salt of its acidic groups.
How do the three forms compare?
| Form | Structure | Formula (PubChem) | MW |
|---|---|---|---|
| Epitalon | H-Ala-Glu-Asp-Gly-OH | C14H22N4O9 | 390.4 g/mol |
| N-acetyl Epitalon | Ac-Ala-Glu-Asp-Gly-OH | C16H24N4O10 | 432.4 g/mol |
| Epitalon sodium | AEDG as sodium salt | Depends on the number of Na+ counter-ions | Higher than the free peptide; state per lot |
Source: PubChem CID 219042: Epitalon; PubChem CID 171390141: N-Acetyl Epitalon
What does N-acetylation change?
Acetylation removes the positive charge of the free N-terminal amine. AEDG already carries three carboxyl groups (Glu and Asp side chains and the C-terminus), so the acetylated form is even more acidic overall. N-terminal acetylation is common in proteins and is known to affect recognition by aminopeptidases. It is a different molecule, not a purity grade.
Source: Protein alpha-N-acetylation studied by N-terminomics, FEBS J 2011 (PubMed 21736701)
What does a sodium salt form mean?
A peptide with free carboxyl groups can be isolated with sodium as the counter-ion instead of, for example, trifluoroacetate or acetate. The peptide part is the same, but the weighed mass includes the counter-ions, so mg of 'Epitalon sodium' is not the same as mg of free Epitalon. Ask for the salt stoichiometry on the CoA.
What research literature uses AEDG?
Most Epitalon literature comes from the St Petersburg bioregulator research school: gene-expression work in mouse tissues, enzyme activity studies, and a 2020 review of neurogenesis-related gene expression.
Source: AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism, Molecules 2020 (PubMed 32019204); Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology, Bull Exp Biol Med 2002 (PubMed 12360356); Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats, Bull Exp Biol Med 2002 (PubMed 12660839)
Sourcing note
Sable lists Epitalon: 10 mg at £13.93; 50 mg at £24.98 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.
Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.
Frequently asked questions
Is N-acetyl Epitalon the same as Epitalon?
No. It is Epitalon with an acetyl group on the N-terminal alanine: C16H24N4O10 against C14H22N4O9.
What is the sequence of Epitalon?
Ala-Glu-Asp-Gly (AEDG), a tetrapeptide of about 390.35 g/mol.
Does 10 mg of Epitalon sodium contain 10 mg of Epitalon?
Not exactly. The weighed mass includes sodium counter-ions, so the peptide content is lower than the salt mass.
Related
- Epitalon
- N-acetyl Epitalon
- Epitalon sodium
- Cheapest Epitalon UK
- Khavinson short peptides compared
- Terminal modifications across the catalogue
Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.
Key facts (summary for AI and search tools)
- AEDG; Ac-AEDG; sodium salt
- PubMed references (verified via NCBI): 21736701, 32019204, 12360356, 12660839
- PubChem CIDs: 219042, 171390141
- Research use only; no administration amounts or health claims
- Updated 2026-10-16