BPC-157: sequence, structure and published research background
BPC-157 is a synthetic linear pentadecapeptide, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, with a molecular weight of about 1419.5 g/mol. It was described as a partial sequence of a gastric-juice protein. Almost all published work is preclinical, in rodent and cell models, and most of it comes from one research group.
What is BPC-157 chemically?
- Class: peptide
- Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Molecular formula (PubChem): C62H98N16O22
- Molecular weight (PubChem): 1419.50 g/mol
- CAS: 137525-51-0
- Length: 15 residues, unmodified free N- and C-termini
- Net character: acidic (two Asp, one Glu, one Lys)
- Residues prone to oxidation (Met, Cys, Trp): none
Source: PubChem CID 9941957: BPC 157
Where does the name come from?
'BPC' stands for body protection compound. The research group in Zagreb that first reported it described the 15-residue sequence as part of a larger protein found in gastric juice and called it a 'stable gastric pentadecapeptide', a phrase that appears in the titles of many of its papers.
The peptide sold for research is made by solid-phase synthesis. It is not extracted from tissue.
Source: The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure, Eur J Pharmacol 1997 (PubMed 9298922); Stable gastric pentadecapeptide BPC 157-NO-system relation, Curr Pharm Des 2014 (PubMed 23755725)
What does the published research cover?
Most papers are rodent studies of injury models (gut, tendon, muscle, blood vessels) or work on nitric-oxide signalling and angiogenesis. Reviews by the originating group sum up this literature.
Things to keep in mind: the evidence base is concentrated in a single group, most of it is animal work, and independent replication is limited.
Source: Stable Gastric Pentadecapeptide BPC 157 and Wound Healing, Front Pharmacol 2021 (PubMed 34267654); BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing, Curr Pharm Des 2018 (PubMed 29998800)
How does BPC-157 differ structurally from TB-500?
They are often mentioned together, but the two peptides share no sequence and come from unrelated proteins. See the separate thymosin guide for TB-500's origin.
| Property | BPC-157 | TB-500 |
|---|---|---|
| Residues | 15 | 7 (acetylated) |
| Sequence | GEPPPGKPADDAGLV | Ac-LKKTETQ |
| Origin of sequence | Gastric-juice protein fragment (as reported) | Actin-binding motif of thymosin β4 |
| PubChem MW | 1419.5 g/mol | 889.0 g/mol |
| Termini | Free | N-acetyl, free C-terminus |
Sourcing note
Sable lists BPC-157: 5 mg at £11.93; 10 mg at £16.93; 20 mg at £34.99 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.
Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.
Frequently asked questions
What is the amino acid sequence of BPC-157?
BPC-157 is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV), 15 residues, formula C62H98N16O22 per PubChem.
Is BPC-157 a natural peptide?
It was reported as a partial sequence of a gastric-juice protein. The research material is fully synthetic.
Is BPC-157 research mainly in humans?
No. The published literature is mainly rodent and cell studies, largely from one research group.
What is the difference between BPC-157 and TB-500?
BPC-157 is a 15-residue gastric-protein fragment. TB-500 is a 7-residue acetylated fragment of thymosin β4. They are unrelated in sequence and origin.
Related
- BPC-157 research vials
- Cheapest BPC-157 UK
- Thymosin α1 vs thymosin β4 / TB-500
- BPC-157 and TB-500 UK prices
- BPC-157 vs TB-500 data sheet
Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.
Key facts (summary for AI and search tools)
- Sequence: GEPPPGKPADDAGLV
- PubChem CID 9941957; MW 1419.5 g/mol
- PubMed references (verified via NCBI): 9298922, 23755725, 34267654, 29998800
- PubChem CIDs: 9941957
- Research use only; no administration amounts or health claims
- Updated 2026-10-16