AOD 9604 and hGH fragment 176-191: what is the relationship?
AOD 9604 is a synthetic 16-residue peptide based on the C-terminal region of human growth hormone, residues 177–191, with a tyrosine added at the N-terminus. Its two cysteines form an intramolecular disulfide. PubChem gives C78H123N23O23S2 at about 1815 g/mol. It is a fragment analogue, not growth hormone.
What is AOD 9604 made of?
- Formula (PubChem): C78H123N23O23S2
- MW (PubChem): 1815.1 g/mol
- CAS: 221231-10-3
- Origin: hGH C-terminal region plus N-terminal Tyr
- Disulfide: one Cys–Cys bridge, as in the native hGH C-terminal loop
Source: PubChem CID 71300630: AOD-9604
Why was a growth hormone fragment studied?
Earlier work suggested that the C-terminal region of hGH carried part of the hormone's lipid-metabolism activity in rodents. A 2001 Endocrinology study compared hGH with its 'lipolytic fragment' AOD9604 in obese mice. A 2004 review summarised the development programme.
Source: The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice, Endocrinology 2001 (PubMed 11713213); AOD-9604 Metabolic, Curr Opin Investig Drugs 2004 (PubMed 15134286)
How is AOD 9604 detected analytically?
Because it is a defined synthetic peptide, AOD 9604 has been the subject of anti-doping analytical work, including detection and in vitro metabolism by LC-MS. This gives a published reference for its fragmentation and metabolites.
Source: Detection and in vitro metabolism of AOD9604, Drug Test Anal 2015 (PubMed 25208511)
How does it differ from full growth hormone?
| Property | AOD 9604 | Human growth hormone |
|---|---|---|
| Length | 16 residues | 191 residues |
| Production | Chemical synthesis | Recombinant expression |
| Mass | ~1.8 kDa | ~22 kDa |
| Disulfides | 1 | 2 |
Sourcing note
Sable lists AOD 9604: 2 mg at £14.29; 5 mg at £14.93; 10 mg at £34.99 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.
Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.
Frequently asked questions
Is AOD 9604 the same as hGH fragment 176-191?
They are closely related. AOD 9604 is described as a tyrosine-modified analogue of the hGH C-terminal fragment.
Does AOD 9604 contain a disulfide?
Yes. Its two cysteines form one intramolecular disulfide bond.
What is the CAS number of AOD 9604?
221231-10-3.
Related
Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.
Key facts (summary for AI and search tools)
- AOD 9604 CID 71300630; CAS 221231-10-3
- PubMed references (verified via NCBI): 11713213, 15134286, 25208511
- PubChem CIDs: 71300630
- Research use only; no administration amounts or health claims
- Updated 2026-10-16