---
title: "What is the amino acid sequence of MOTS-c? | Sable Peptides"
description: "MOTS-c is a research peptide whose amino acid sequence is on the public registry record. The published sequence is…"
canonical: https://www.sablepeptides.co.uk/questions/mots-c-sequence
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

# What is the amino acid sequence of MOTS-c?

MOTS-c is a research peptide whose amino acid sequence is on the public registry record. The published sequence is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg. Its molecular formula is C101H152N28O22S2. Its molecular weight is 2174.6 g/mol. The CAS Registry Number is 1627580-64-6. PubChem CID 146675088 indexes the structure.

Sequence. Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Class. peptide.

Formula. C101H152N28O22S2.

Mass. 2174.6 g/mol.

Analytical note. Identity confirmation by mass spectrometry uses the mass calculated from the formula. Sable's release specification is ≥99% by HPLC with identity confirmed against the expected mass (quality page). Research use only. Not a medicine. Not for human or veterinary use.

## Sources

-   [https://pubchem.ncbi.nlm.nih.gov/compound/146675088](https://pubchem.ncbi.nlm.nih.gov/compound/146675088)

## MOTS-c: reference facts

8 MOTS-c values, each linked to its public source; see the [MOTS-c reference page](/ref/mots-c).

| Synonyms | mitochondrial ORF of the 12S rRNA type-c (pubchem.ncbi.nlm.nih.gov) |
| --- | --- |
| Compound class | peptide (pubchem.ncbi.nlm.nih.gov) |
| CAS Registry Number | 1627580-64-6 (pubchem.ncbi.nlm.nih.gov) |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (pubchem.ncbi.nlm.nih.gov) |
| Molecular formula | C101H152N28O22S2 (pubchem.ncbi.nlm.nih.gov) |
| Molecular weight | 2174.6 g/mol (pubchem.ncbi.nlm.nih.gov) |
| PubChem CID | 146675088 (pubchem.ncbi.nlm.nih.gov) |
| Storage (lyophilised) | -20 °C, dry, protected from light (sigmaaldrich.com) |

## Calculated sequence properties

Computed from the listed sequence. See the [methodology](/data/methodology).

| Length | 16 residues |
| --- | --- |
| Theoretical pI | 10.64 (calculated from sequence) |
| Net charge at pH 7 | 2.98 (calculated) |
| Extinction coefficient, 280 nm | 8480 M⁻¹cm⁻¹ (calculated) |

## Sizes and prices at Sable

| Vial | Price | Per mg | UK same-size check (2026-10-16) |
| --- | --- | --- | --- |
| 5 mg | £9.85 | £1.97 | lowest other £19.50 across 1 UK sellers |
| 10 mg | £14.97 | £1.50 | lowest other £14.99 across 17 UK sellers |
| 20 mg | £28.98 | £1.45 | lowest other £35.00 across 3 UK sellers |
| 30 mg | £42.19 | £1.41 | no same-size match |
| 40 mg | £39.97 | £1.00 | lowest other £39.99 across 11 UK sellers |

Multi-vial pricing on the same item: 3+ vials 10% off, 5+ vials 15% off, 10+ vials 20% off. Every lot has a certificate of analysis: [CoA library](/coa).

## Typical analytical method

| HPLC column | C18 reversed-phase (100-120 A pore) |
| --- | --- |
| Mobile phase | A: water + 0.1% TFA; B: acetonitrile + 0.1% TFA; linear gradient (e.g. 5-65% B over 20-30 min) |
| Detection | 214-220 nm (peptide bond) and 280 nm (Trp/Tyr present) |

General literature method. The lot CoA records the method actually used. [How to read an HPLC chromatogram](/learn/how-to-read-an-hplc-chromatogram).

## Related questions

-   [What is the molecular formula of MOTS-c?](/questions/mots-c-molecular-formula)
-   [What does MOTS-c dissolve in?](/questions/mots-c-solubility)
-   [How stable is lyophilised MOTS-c?](/questions/mots-c-stability-lyophilised)

## Lyophilised storage on file: MOTS-c

From the Sable storage reference (lyophilised material only; temperature, light, moisture). Literature basis is linked per row. See [peptide storage](/learn/peptide-storage-and-solubility).

| Compound | Lyophilised storage | Light / notes |
| --- | --- | --- |
| MOTS-c | -20 C long term (-80 C acceptable), sealed and desiccated; 2-8 C for weeks | protect from light; contains Met/Cys/Trp: oxidation-prone; minimise air/headspace exposure (source) |

## Typical analytical method: MOTS-c

Reference HPLC and MS conditions from the Sable analytical-methods file; a lot's CoA states the method actually used. See [how to read a CoA](/guides/how-to-read-a-coa).

| Compound | HPLC column / detection | MS / expected ion |
| --- | --- | --- |
| MOTS-c | C18 reversed-phase (100-120 A pore); 214-220 nm (peptide bond) and 280 nm (Trp/Tyr present) | ESI-MS (positive mode); LC-MS for identity; [M+1H]1+ ~2175.6; [M+2H]2+ ~1088.3; [M+3H]3+ ~725.9 |

Research use only. Not a medicine. Not for human or veterinary use.