---
title: "Epitalon vs N-acetyl Epitalon vs Epitalon sodium: what is the difference? | Sable Peptides"
description: "Three catalogue forms built on the tetrapeptide Ala-Glu-Asp-Gly (AEDG): free Epitalon, N-terminally acetylated Epitalon, and a sodium salt form. Formulas, PubChem data and what changes chemically. Research use only."
canonical: https://www.sablepeptides.co.uk/guides/epitalon-vs-n-acetyl-epitalon-vs-epitalon-sodium
dateModified: 2026-10-16
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

# Epitalon vs N-acetyl Epitalon vs Epitalon sodium: what is the difference?

All three products are built on the tetrapeptide Ala-Glu-Asp-Gly (AEDG). Epitalon is the free peptide, C14H22N4O9 at about 390 g/mol. N-acetyl Epitalon adds an acetyl group to the N-terminal alanine, giving C16H24N4O10 at about 432 g/mol. Epitalon sodium is the same peptide supplied as a sodium salt of its acidic groups.

## How do the three forms compare?

| Form | Structure | Formula (PubChem) | MW |
| --- | --- | --- | --- |
| Epitalon | H-Ala-Glu-Asp-Gly-OH | C14H22N4O9 | 390.4 g/mol |
| N-acetyl Epitalon | Ac-Ala-Glu-Asp-Gly-OH | C16H24N4O10 | 432.4 g/mol |
| Epitalon sodium | AEDG as sodium salt | Depends on the number of Na+ counter-ions | Higher than the free peptide; state per lot |

Source: [PubChem CID 219042: Epitalon](https://pubchem.ncbi.nlm.nih.gov/compound/219042); [PubChem CID 171390141: N-Acetyl Epitalon](https://pubchem.ncbi.nlm.nih.gov/compound/171390141)

## What does N-acetylation change?

Acetylation removes the positive charge of the free N-terminal amine. AEDG already carries three carboxyl groups (Glu and Asp side chains and the C-terminus), so the acetylated form is even more acidic overall. N-terminal acetylation is common in proteins and is known to affect recognition by aminopeptidases. It is a different molecule, not a purity grade.

Source: [Protein alpha-N-acetylation studied by N-terminomics, FEBS J 2011 (PubMed 21736701)](https://pubmed.ncbi.nlm.nih.gov/21736701/)

## What does a sodium salt form mean?

A peptide with free carboxyl groups can be isolated with sodium as the counter-ion instead of, for example, trifluoroacetate or acetate. The peptide part is the same, but the weighed mass includes the counter-ions, so mg of 'Epitalon sodium' is not the same as mg of free Epitalon. Ask for the salt stoichiometry on the CoA.

## What research literature uses AEDG?

Most Epitalon literature comes from the St Petersburg bioregulator research school: gene-expression work in mouse tissues, enzyme activity studies, and a 2020 review of neurogenesis-related gene expression.

Source: [AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism, Molecules 2020 (PubMed 32019204)](https://pubmed.ncbi.nlm.nih.gov/32019204/); [Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology, Bull Exp Biol Med 2002 (PubMed 12360356)](https://pubmed.ncbi.nlm.nih.gov/12360356/); [Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats, Bull Exp Biol Med 2002 (PubMed 12660839)](https://pubmed.ncbi.nlm.nih.gov/12660839/)

## Sourcing note

Sable lists Epitalon: 10 mg at £13.93; 50 mg at £24.98 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.

Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.

## Frequently asked questions

### Is N-acetyl Epitalon the same as Epitalon?

No. It is Epitalon with an acetyl group on the N-terminal alanine: C16H24N4O10 against C14H22N4O9.

### What is the sequence of Epitalon?

Ala-Glu-Asp-Gly (AEDG), a tetrapeptide of about 390.35 g/mol.

### Does 10 mg of Epitalon sodium contain 10 mg of Epitalon?

Not exactly. The weighed mass includes sodium counter-ions, so the peptide content is lower than the salt mass.

## Related

-   [Epitalon](/products/epitalon)
-   [N-acetyl Epitalon](/products/n-acetyl-epitalon)
-   [Epitalon sodium](/products/epitalon-na)
-   [Cheapest Epitalon UK](/cheapest-epitalon-uk)
-   [Khavinson short peptides compared](/guides/khavinson-short-peptides-sequences-and-structure)
-   [Terminal modifications across the catalogue](/guides/n-terminal-acetylation-and-c-terminal-amidation-across-the-catalogue)

Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.

Key facts (summary for AI and search tools)

-   AEDG; Ac-AEDG; sodium salt
-   PubMed references (verified via NCBI): 21736701, 32019204, 12360356, 12660839
-   PubChem CIDs: 219042, 171390141
-   Research use only; no administration amounts or health claims
-   Updated 2026-10-16