---
title: "DSIP (delta sleep-inducing peptide): structure and history | Sable Peptides"
description: "DSIP is the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first reported in 1977 from rabbit blood. Its sequence, PubChem data, the unresolved question of its gene, and review literature. Research use only."
canonical: https://www.sablepeptides.co.uk/guides/dsip-delta-sleep-inducing-peptide-structure-and-history
dateModified: 2026-10-16
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

# DSIP (delta sleep-inducing peptide): structure and history

DSIP, delta sleep-inducing peptide, is the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, about 849 g/mol. It was isolated in 1977 from the venous blood of rabbits during electrically induced sleep and named for an EEG effect seen in those experiments. A gene or precursor protein for it has never been clearly identified.

## What is the structure of DSIP?

-   Class: peptide
-   Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
-   Molecular formula (PubChem): C35H48N10O15
-   Molecular weight (PubChem): 848.80 g/mol
-   CAS: 62568-57-4
-   Termini: free N-terminal Trp, free C-terminal Glu
-   Oxidation-prone residue: Trp1

Source: [PubChem CID 68816: Delta sleep-inducing peptide](https://pubchem.ncbi.nlm.nih.gov/compound/68816)

## How was DSIP discovered?

The Basel group of Monnier and Schoenenberger characterised a peptide from cerebral venous blood of sleeping rabbits that induced delta EEG activity in recipient animals. They then sequenced and synthesised it as a nonapeptide.

Source: [Characterization of a delta-electroencephalogram (-sleep)-inducing peptide, Proc Natl Acad Sci U S A 1977 (PubMed 265572)](https://pubmed.ncbi.nlm.nih.gov/265572/); [The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide, Pflugers Arch 1978 (PubMed 568769)](https://pubmed.ncbi.nlm.nih.gov/568769/)

## Why is DSIP called an unresolved riddle?

Despite decades of work, no DSIP-encoding gene or specific receptor was confirmed, and reported effects varied between laboratories. A 2006 review is titled after this ambiguity. Earlier reviews (1984, 2001) cover the wider pharmacology literature.

Source: [Delta sleep-inducing peptide (DSIP): a still unresolved riddle, J Neurochem 2006 (PubMed 16539679)](https://pubmed.ncbi.nlm.nih.gov/16539679/); [Delta-sleep-inducing peptide (DSIP): a review, Neurosci Biobehav Rev 1984 (PubMed 6145137)](https://pubmed.ncbi.nlm.nih.gov/6145137/); [Delta sleep-inducing peptide, Eur J Anaesthesiol 2001 (PubMed 11437870)](https://pubmed.ncbi.nlm.nih.gov/11437870/)

## Sourcing note

Sable lists DSIP: 5 mg at £11.56 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.

Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.

## Frequently asked questions

### What is the sequence of DSIP?

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE).

### Has the DSIP gene been found?

No gene or precursor has been clearly identified, which is one reason reviews call DSIP an unresolved riddle.

### When was DSIP discovered?

It was characterised in 1977 (PNAS) by Schoenenberger and Monnier's group.

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Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.

Key facts (summary for AI and search tools)

-   DSIP CID 68816
-   Discovered 1977 (PubMed 265572)
-   PubMed references (verified via NCBI): 265572, 568769, 16539679, 6145137, 11437870
-   PubChem CIDs: 68816
-   Research use only; no administration amounts or health claims
-   Updated 2026-10-16