---
title: "Cagrilintide: what is a long-acting amylin analogue? | Sable Peptides"
description: "Cagrilintide is a lipidated analogue of the 37-residue pancreatic hormone amylin, designed for stability and long action, with activity at amylin and calcitonin receptors. Structure, PubChem data and literature."
canonical: https://www.sablepeptides.co.uk/guides/cagrilintide-long-acting-amylin-analogue-explained
dateModified: 2026-10-16
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

# Cagrilintide: what is a long-acting amylin analogue?

Cagrilintide is a long-acting, lipidated analogue of amylin, the 37-residue peptide hormone co-secreted with insulin. It keeps amylin's N-terminal disulfide ring, adds a fatty diacid for albumin binding and carries substitutions that reduce amylin's strong tendency to form fibrils. PubChem gives its formula as C194H312N54O59S2.

## What is amylin and why was it modified?

Native human amylin aggregates readily into amyloid fibrils, which makes it hard to formulate and handle. Analogue programmes swap in fibril-breaking residues and add half-life extension. Recent reviews trace this line from physiology to long-acting analogues.

Source: [The story of amylin: from physiology to therapy, Nat Metab 2026 (PubMed 41708975)](https://pubmed.ncbi.nlm.nih.gov/41708975/); [Long-acting amylin-related peptides as therapies for obesity and type 2 diabetes, Peptides 2026 (PubMed 41747885)](https://pubmed.ncbi.nlm.nih.gov/41747885/)

## How was cagrilintide designed?

The 2021 J Med Chem paper describes cagrilintide's development: the backbone was optimised for chemical and physical stability, and a fatty diacid side chain was added for albumin binding. It acts at amylin receptors (calcitonin receptor plus RAMP) and at the calcitonin receptor itself.

Source: [Development of Cagrilintide, a Long-Acting Amylin Analogue, J Med Chem 2021 (PubMed 34288673)](https://pubmed.ncbi.nlm.nih.gov/34288673/)

## What do structural studies show about binding?

A 2025 cryo-EM and dynamics study compared cagrilintide bound to calcitonin and amylin receptors and described the features that explain its non-selective profile.

Source: [Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors, Nat Commun 2025 (PubMed 40204768)](https://pubmed.ncbi.nlm.nih.gov/40204768/)

## What are its identity data?

-   Formula (PubChem): C194H312N54O59S2
-   MW (PubChem): 4409.0 g/mol
-   Disulfide: one intramolecular bridge in the N-terminal ring
-   Lipidation: N-terminal fatty diacid

Source: [PubChem CID 171397054: Cagrilintide](https://pubchem.ncbi.nlm.nih.gov/compound/171397054)

## Sourcing note

Sable lists Cagrilintide: 5 mg at £28.98; 10 mg at £43.99 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.

Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.

## Frequently asked questions

### Is cagrilintide a GLP-1 agonist?

No. It is an amylin analogue acting at amylin and calcitonin receptors.

### Why does native amylin need modifying?

Human amylin aggregates into fibrils readily. Cagrilintide's sequence changes improve stability, and its lipidation extends its action.

### What is the molecular weight of cagrilintide?

About 4409 g/mol (PubChem CID 171397054).

## Related

-   [Cagrilintide research vials](/products/cagrilintide)
-   [Semaglutide vs tirzepatide vs retatrutide](/guides/semaglutide-vs-tirzepatide-vs-retatrutide-structures)
-   [Buyer checklist: lipidated peptides](/guides/buyer-checklist-for-lipidated-incretin-research-peptides)

Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.

Key facts (summary for AI and search tools)

-   Cagrilintide CID 171397054
-   Amylin/calcitonin receptor agonist
-   PubMed references (verified via NCBI): 41708975, 41747885, 34288673, 40204768
-   PubChem CIDs: 171397054
-   Research use only; no administration amounts or health claims
-   Updated 2026-10-16