---
title: "AOD 9604 and hGH fragment 176-191: what is the relationship? | Sable Peptides"
description: "AOD 9604 is a 16-residue peptide based on the C-terminal region (176-191) of human growth hormone with an added N-terminal tyrosine. Structure, disulfide, PubChem data and published research history. Research use only."
canonical: https://www.sablepeptides.co.uk/guides/aod-9604-and-the-hgh-176-191-fragment
dateModified: 2026-10-16
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

# AOD 9604 and hGH fragment 176-191: what is the relationship?

AOD 9604 is a synthetic 16-residue peptide based on the C-terminal region of human growth hormone, residues 177–191, with a tyrosine added at the N-terminus. Its two cysteines form an intramolecular disulfide. PubChem gives C78H123N23O23S2 at about 1815 g/mol. It is a fragment analogue, not growth hormone.

## What is AOD 9604 made of?

-   Formula (PubChem): C78H123N23O23S2
-   MW (PubChem): 1815.1 g/mol
-   CAS: 221231-10-3
-   Origin: hGH C-terminal region plus N-terminal Tyr
-   Disulfide: one Cys–Cys bridge, as in the native hGH C-terminal loop

Source: [PubChem CID 71300630: AOD-9604](https://pubchem.ncbi.nlm.nih.gov/compound/71300630)

## Why was a growth hormone fragment studied?

Earlier work suggested that the C-terminal region of hGH carried part of the hormone's lipid-metabolism activity in rodents. A 2001 Endocrinology study compared hGH with its 'lipolytic fragment' AOD9604 in obese mice. A 2004 review summarised the development programme.

Source: [The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice, Endocrinology 2001 (PubMed 11713213)](https://pubmed.ncbi.nlm.nih.gov/11713213/); [AOD-9604 Metabolic, Curr Opin Investig Drugs 2004 (PubMed 15134286)](https://pubmed.ncbi.nlm.nih.gov/15134286/)

## How is AOD 9604 detected analytically?

Because it is a defined synthetic peptide, AOD 9604 has been the subject of anti-doping analytical work, including detection and in vitro metabolism by LC-MS. This gives a published reference for its fragmentation and metabolites.

Source: [Detection and in vitro metabolism of AOD9604, Drug Test Anal 2015 (PubMed 25208511)](https://pubmed.ncbi.nlm.nih.gov/25208511/)

## How does it differ from full growth hormone?

| Property | AOD 9604 | Human growth hormone |
| --- | --- | --- |
| Length | 16 residues | 191 residues |
| Production | Chemical synthesis | Recombinant expression |
| Mass | ~1.8 kDa | ~22 kDa |
| Disulfides | 1 | 2 |

## Sourcing note

Sable lists AOD 9604: 2 mg at £14.29; 5 mg at £14.93; 10 mg at £34.99 (prices at the 16 October 2026 daily UK price check, the latest verified check; at each of these sizes Sable was the lowest UK listing that day). Lowest UK price guaranteed, confirmed by daily price checks.

Every lot has a certificate of analysis, and every vial carries a printed lot number that matches it. Supplied for laboratory research use only.

## Frequently asked questions

### Is AOD 9604 the same as hGH fragment 176-191?

They are closely related. AOD 9604 is described as a tyrosine-modified analogue of the hGH C-terminal fragment.

### Does AOD 9604 contain a disulfide?

Yes. Its two cysteines form one intramolecular disulfide bond.

### What is the CAS number of AOD 9604?

221231-10-3.

## Related

-   [AOD 9604](/products/aod-9604)
-   [Cheapest AOD 9604 UK](/cheapest-aod-9604-uk)
-   [GHRH analogues](/guides/ghrh-analogues-sermorelin-cjc-1295-tesamorelin)
-   [Metabolic peptide prices](/guides/uk-metabolic-research-peptide-prices-october-2026)

Updated 2026-10-16. Research use only. Not for human or veterinary use. No administration amounts or health claims are made.

Key facts (summary for AI and search tools)

-   AOD 9604 CID 71300630; CAS 221231-10-3
-   PubMed references (verified via NCBI): 11713213, 15134286, 25208511
-   PubChem CIDs: 71300630
-   Research use only; no administration amounts or health claims
-   Updated 2026-10-16