---
title: "Trypsin: research glossary | Sable Peptides"
description: "Trypsin is a serine protease that cleaves peptide chains mainly on the carboxyl side of lysine and arginine residues, except when followed by proline. It i"
canonical: https://www.sablepeptides.co.uk/glossary/trypsin
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Trypsin

Trypsin is a serine protease that cleaves peptide chains mainly on the carboxyl side of lysine and arginine residues, except when followed by proline. It is widely used in proteomics to digest proteins into peptides for mass spectrometry analysis and in cell culture to detach adherent cells.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Trypsin)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Mass spectrometry](/glossary/mass-spectrometry)
-   [Cell culture](/glossary/cell-culture)
-   [Protease](/glossary/protease)
-   [Proline](/glossary/proline)
-   [Serine](/glossary/serine)
-   [Lysine](/glossary/lysine)
-   [Arginine](/glossary/arginine)

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