---
title: "Tris buffer: research glossary | Sable Peptides"
description: "Tris, or tris(hydroxymethyl)aminomethane, is a widely used biological buffer with a useful range of about pH 7 to 9. Its pKa varies noticeably with tempera"
canonical: https://www.sablepeptides.co.uk/glossary/tris-buffer
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Tris buffer

Tris, or tris(hydroxymethyl)aminomethane, is a widely used biological buffer with a useful range of about pH 7 to 9. Its pKa varies noticeably with temperature, so pH should be adjusted at the working temperature. Tris contains a primary amine, which can interfere with amine-reactive labelling chemistry.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Tris)

## Related terms

-   [Buffer](/glossary/buffer)

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