---
title: "Trifluoroacetic acid: research glossary | Sable Peptides"
description: "Trifluoroacetic acid (TFA, CF3COOH) is a strong, volatile organic acid widely used in peptide chemistry. It cleaves peptides from resin in Fmoc synthesis a"
canonical: https://www.sablepeptides.co.uk/glossary/trifluoroacetic-acid
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Trifluoroacetic acid

Trifluoroacetic acid (TFA, CF3COOH) is a strong, volatile organic acid widely used in peptide chemistry. It cleaves peptides from resin in Fmoc synthesis and is a common ion-pairing additive in reversed-phase HPLC mobile phases, usually at about 0.1%. Because it is used in purification, synthetic peptides are often isolated as TFA salts.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Trifluoroacetic_acid)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Resin](/glossary/resin)

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