---
title: "TFA salt: research glossary | Sable Peptides"
description: "A TFA salt is the form in which many synthetic peptides are isolated after reversed-phase HPLC purification with trifluoroacetic acid. Trifluoroacetate cou"
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publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# TFA salt

A TFA salt is the form in which many synthetic peptides are isolated after reversed-phase HPLC purification with trifluoroacetic acid. Trifluoroacetate counter-ions pair with basic groups such as lysine, arginine, histidine and the free N-terminus. These counter-ions add to the gross weight of the powder, so net peptide content is lower than the weighed mass.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Trifluoroacetic_acid)

## Related terms

-   [Peptide](/glossary/peptide)
-   [N-terminus](/glossary/n-terminus)
-   [Trifluoroacetic acid](/glossary/trifluoroacetic-acid)
-   [Net peptide content](/glossary/net-peptide-content)
-   [Gross weight](/glossary/gross-weight)
-   [Lysine](/glossary/lysine)
-   [Arginine](/glossary/arginine)
-   [Histidine](/glossary/histidine)

[Back to glossary A–Z](/glossary/terms)

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