---
title: "TCEP: research glossary | Sable Peptides"
description: "Tris(2-carboxyethyl)phosphine (TCEP) is a thiol-free reducing agent that cleaves disulfide bonds. Compared with DTT it is odourless, more stable in air and"
canonical: https://www.sablepeptides.co.uk/glossary/tcep
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# TCEP

Tris(2-carboxyethyl)phosphine (TCEP) is a thiol-free reducing agent that cleaves disulfide bonds. Compared with DTT it is odourless, more stable in air and effective across a wider pH range, and it does not need removal before maleimide labelling in many protocols. It is supplied as a hydrochloride salt.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/TCEP)

## Related terms

-   [Maleimide](/glossary/maleimide)

[Back to glossary A–Z](/glossary/terms)

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