---
title: "Stapled peptide: research glossary | Sable Peptides"
description: "A stapled peptide is a peptide in which a synthetic brace, typically an all-hydrocarbon cross-link formed by ring-closing metathesis between two non-natura"
canonical: https://www.sablepeptides.co.uk/glossary/stapled-peptide
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Stapled peptide

A stapled peptide is a peptide in which a synthetic brace, typically an all-hydrocarbon cross-link formed by ring-closing metathesis between two non-natural amino acids, locks it into an alpha-helical conformation. Stapling can improve helicity, proteolytic stability and cell permeability and is used to target protein-protein interactions in research.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Stapled_peptide)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Proteolytic stability](/glossary/proteolytic-stability)

[Back to glossary A–Z](/glossary/terms)

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