---
title: "Solid-phase peptide synthesis: research glossary | Sable Peptides"
description: "Solid-phase peptide synthesis (SPPS) builds a peptide one amino acid at a time on an insoluble polymer resin, from the C-terminus to the N-terminus. Repeat"
canonical: https://www.sablepeptides.co.uk/glossary/solid-phase-peptide-synthesis
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Solid-phase peptide synthesis

Solid-phase peptide synthesis (SPPS) builds a peptide one amino acid at a time on an insoluble polymer resin, from the C-terminus to the N-terminus. Repeated cycles of deprotection, coupling and washing allow excess reagents to be removed by filtration. Developed by Bruce Merrifield, it is the standard method for producing synthetic research peptides.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Peptide_synthesis)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Amino acid](/glossary/amino-acid)
-   [N-terminus](/glossary/n-terminus)
-   [C-terminus](/glossary/c-terminus)
-   [Resin](/glossary/resin)
-   [Filtration](/glossary/filtration)

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