---
title: "Salt exchange: research glossary | Sable Peptides"
description: "Salt exchange, or counter-ion exchange, replaces one counter-ion associated with a peptide with another, most commonly converting a TFA salt to an acetate"
canonical: https://www.sablepeptides.co.uk/glossary/salt-exchange
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Salt exchange

Salt exchange, or counter-ion exchange, replaces one counter-ion associated with a peptide with another, most commonly converting a TFA salt to an acetate or hydrochloride salt. It can be performed with ion-exchange resins, repeated lyophilisation from dilute hydrochloric acid, or preparative HPLC using a different acid modifier. The exchange is verified by ion chromatography or fluorine NMR.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Ion_exchange)

## Related terms

-   [Peptide](/glossary/peptide)
-   [TFA salt](/glossary/tfa-salt)
-   [Counter-ion](/glossary/counter-ion)
-   [Lyophilisation](/glossary/lyophilisation)
-   [Preparative HPLC](/glossary/preparative-hplc)
-   [Ion chromatography](/glossary/ion-chromatography)

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