---
title: "Retro-inverso peptide: research glossary | Sable Peptides"
description: "A retro-inverso peptide is composed of D-amino acids assembled in the reverse sequence order of a parent L-peptide. This arrangement approximates the side-"
canonical: https://www.sablepeptides.co.uk/glossary/retro-inverso-peptide
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Retro-inverso peptide

A retro-inverso peptide is composed of D-amino acids assembled in the reverse sequence order of a parent L-peptide. This arrangement approximates the side-chain topology of the original while reversing the backbone direction, typically conferring high resistance to proteases. FOXO4-DRI is an example of a D-retro-inverso research peptide.

Source: [pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC8395423/)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Sequence](/glossary/sequence)

## Reference data

-   [Foxo4-Dri](/ref/foxo4-dri)

## Related products

-   [https://www.sablepeptides.co.uk/product/foxo4-dri-5mg](https://www.sablepeptides.co.uk/product/foxo4-dri-5mg)

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