---
title: "Residual solvent: research glossary | Sable Peptides"
description: "A residual solvent is an organic volatile chemical used or produced during manufacture that is not completely removed. In peptide synthesis, possible resid"
canonical: https://www.sablepeptides.co.uk/glossary/residual-solvent
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Residual solvent

A residual solvent is an organic volatile chemical used or produced during manufacture that is not completely removed. In peptide synthesis, possible residual solvents include acetonitrile, diethyl ether, DMF and dichloromethane. They are measured by gas chromatography, often with headspace sampling, against defined limits.

Source: [ema.europa.eu](https://www.ema.europa.eu/en/ich-q3c-r9-residual-solvents-scientific-guideline)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Acetonitrile](/glossary/acetonitrile)
-   [Gas chromatography](/glossary/gas-chromatography)
-   [Diethyl ether](/glossary/diethyl-ether)
-   [Dichloromethane](/glossary/dichloromethane)

[Back to glossary A–Z](/glossary/terms)

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