---
title: "Racemisation: research glossary | Sable Peptides"
description: "Racemisation is the conversion of a chiral compound into a mixture of its enantiomers. In peptide synthesis, activated amino acids, especially cysteine and"
canonical: https://www.sablepeptides.co.uk/glossary/racemisation
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Racemisation

Racemisation is the conversion of a chiral compound into a mixture of its enantiomers. In peptide synthesis, activated amino acids, especially cysteine and histidine, can partially convert from the L- to the D-configuration. The resulting diastereomeric peptides may be difficult to separate and can be detected by chiral chromatography or careful HPLC method development.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Racemization)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Cysteine](/glossary/cysteine)
-   [Histidine](/glossary/histidine)

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