---
title: "Proteolytic stability: research glossary | Sable Peptides"
description: "Proteolytic stability is the resistance of a peptide to degradation by protease enzymes. Natural linear peptides are often rapidly degraded in biological m"
canonical: https://www.sablepeptides.co.uk/glossary/proteolytic-stability
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Proteolytic stability

Proteolytic stability is the resistance of a peptide to degradation by protease enzymes. Natural linear peptides are often rapidly degraded in biological matrices. Strategies to improve stability include D-amino acid substitution, cyclisation, N-methylation, terminal capping and lipidation, which are evaluated in serum or enzyme stability assays.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Proteolysis)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Amino acid](/glossary/amino-acid)
-   [D-amino acid](/glossary/d-amino-acid)
-   [Lipidation](/glossary/lipidation)
-   [Protease](/glossary/protease)
-   [Capping](/glossary/capping)
-   [N-methylation](/glossary/n-methylation)

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