---
title: "Piperidine: research glossary | Sable Peptides"
description: "Piperidine is a cyclic secondary amine used, typically as a 20% solution in DMF, to remove the Fmoc protecting group during solid-phase peptide synthesis."
canonical: https://www.sablepeptides.co.uk/glossary/piperidine
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Piperidine

Piperidine is a cyclic secondary amine used, typically as a 20% solution in DMF, to remove the Fmoc protecting group during solid-phase peptide synthesis. It also traps the dibenzofulvene by-product. Its use is controlled in some jurisdictions, and alternatives such as 4-methylpiperidine are sometimes used.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Piperidine)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Solid-phase peptide synthesis](/glossary/solid-phase-peptide-synthesis)
-   [Protecting group](/glossary/protecting-group)

[Back to glossary A–Z](/glossary/terms)

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