---
title: "Peak tailing: research glossary | Sable Peptides"
description: "Peak tailing is an asymmetry in a chromatographic peak in which the trailing edge is broader than the leading edge. In peptide HPLC it can arise from secon"
canonical: https://www.sablepeptides.co.uk/glossary/peak-tailing
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Peak tailing

Peak tailing is an asymmetry in a chromatographic peak in which the trailing edge is broader than the leading edge. In peptide HPLC it can arise from secondary interactions with residual silanols, column overload or degradation. Ion-pairing agents such as TFA reduce tailing of basic peptides.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Chromatography)

## Related terms

-   [Peptide](/glossary/peptide)

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