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title: "Orthogonal protection: research glossary | Sable Peptides"
description: "Orthogonal protection is a strategy in which different protecting groups in the same molecule can be removed independently using distinct conditions, such"
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---

Glossary

# Orthogonal protection

Orthogonal protection is a strategy in which different protecting groups in the same molecule can be removed independently using distinct conditions, such as base, acid, or palladium catalysis. In Fmoc/tBu peptide synthesis, the base-labile Fmoc group is removed each cycle while acid-labile side-chain groups remain intact until final cleavage, enabling controlled chain assembly and selective modification.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Protecting_group#Orthogonal_protection)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Cleavage](/glossary/cleavage)

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