---
title: "Native chemical ligation: research glossary | Sable Peptides"
description: "Native chemical ligation is a method for joining two unprotected peptide fragments, one bearing a C-terminal thioester and the other an N-terminal cysteine"
canonical: https://www.sablepeptides.co.uk/glossary/native-chemical-ligation
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Native chemical ligation

Native chemical ligation is a method for joining two unprotected peptide fragments, one bearing a C-terminal thioester and the other an N-terminal cysteine, to form a native peptide bond. It enables chemical synthesis of long peptides and small proteins beyond the practical length limit of stepwise solid-phase synthesis.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Native_chemical_ligation)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Peptide bond](/glossary/peptide-bond)
-   [Cysteine](/glossary/cysteine)

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