---
title: "N-Methyl-2-pyrrolidone: research glossary | Sable Peptides"
description: "N-Methyl-2-pyrrolidone (NMP) is a polar aprotic solvent used as an alternative to DMF in solid-phase peptide synthesis, sometimes improving solvation of ag"
canonical: https://www.sablepeptides.co.uk/glossary/n-methyl-2-pyrrolidone
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# N-Methyl-2-pyrrolidone

N-Methyl-2-pyrrolidone (NMP) is a polar aprotic solvent used as an alternative to DMF in solid-phase peptide synthesis, sometimes improving solvation of aggregating sequences. Like DMF, it is classified as a reproductive toxicant and is subject to regulatory restrictions in Europe and the UK.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/N-Methyl-2-pyrrolidone)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Solid-phase peptide synthesis](/glossary/solid-phase-peptide-synthesis)

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