---
title: "Monoisotopic mass: research glossary | Sable Peptides"
description: "Monoisotopic mass is the mass of a molecule calculated using the most abundant isotope of each element, such as carbon-12, hydrogen-1, nitrogen-14 and oxyg"
canonical: https://www.sablepeptides.co.uk/glossary/monoisotopic-mass
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Monoisotopic mass

Monoisotopic mass is the mass of a molecule calculated using the most abundant isotope of each element, such as carbon-12, hydrogen-1, nitrogen-14 and oxygen-16. High-resolution mass spectrometers resolve isotopic peaks, so the monoisotopic peak is used to confirm peptide identity. It is lower than the average mass, especially for larger peptides.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Monoisotopic_mass)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Average mass](/glossary/average-mass)
-   [Resolution](/glossary/resolution)

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