---
title: "Maleimide: research glossary | Sable Peptides"
description: "Maleimide is a reactive group that forms stable thioether bonds with thiol groups, such as cysteine side chains, at near-neutral pH. Maleimide reagents are"
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note: Research use only. Not for human or veterinary use.
---

Glossary

# Maleimide

Maleimide is a reactive group that forms stable thioether bonds with thiol groups, such as cysteine side chains, at near-neutral pH. Maleimide reagents are widely used for site-specific labelling and conjugation of cysteine-containing peptides. The resulting thiosuccinimide linkage can undergo slow exchange or hydrolysis.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Maleimide)

## Related terms

-   [Hydrolysis](/glossary/hydrolysis)
-   [Cysteine](/glossary/cysteine)
-   [Conjugation](/glossary/conjugation)

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