---
title: "Lipidation: research glossary | Sable Peptides"
description: "Lipidation is the covalent attachment of a fatty acid or other lipid moiety to a peptide or protein. In research peptides, palmitoyl or other acyl chains m"
canonical: https://www.sablepeptides.co.uk/glossary/lipidation
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Lipidation

Lipidation is the covalent attachment of a fatty acid or other lipid moiety to a peptide or protein. In research peptides, palmitoyl or other acyl chains may be attached to lysine side chains or the N-terminus, sometimes through a spacer. Lipidation increases hydrophobicity, can promote binding to albumin and changes retention behaviour in reversed-phase HPLC.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Lipidation)

## Related terms

-   [Peptide](/glossary/peptide)
-   [N-terminus](/glossary/n-terminus)
-   [Hydrophobicity](/glossary/hydrophobicity)
-   [Lysine](/glossary/lysine)

[Back to glossary A–Z](/glossary/terms)

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