---
title: "Limit of detection: research glossary | Sable Peptides"
description: "The limit of detection (LOD) is the lowest amount of an analyte that can be reliably distinguished from background noise, though not necessarily quantified"
canonical: https://www.sablepeptides.co.uk/glossary/limit-of-detection
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Limit of detection

The limit of detection (LOD) is the lowest amount of an analyte that can be reliably distinguished from background noise, though not necessarily quantified with acceptable precision. It is often estimated as the concentration giving a signal-to-noise ratio of about 3:1 and is relevant to detecting trace peptide impurities.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Detection_limit)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Signal-to-noise ratio](/glossary/signal-to-noise-ratio)
-   [Precision](/glossary/precision)

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