---
title: "Karl Fischer titration: research glossary | Sable Peptides"
description: "Karl Fischer titration is an analytical method for determining water content using a reaction between water, iodine and sulfur dioxide in the presence of a"
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publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Karl Fischer titration

Karl Fischer titration is an analytical method for determining water content using a reaction between water, iodine and sulfur dioxide in the presence of a base and alcohol. Coulometric versions measure very small amounts of water. It is used to quantify residual moisture in lyophilised peptide powders.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Karl_Fischer_titration)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Water content](/glossary/water-content)

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