---
title: "Ion-exchange chromatography: research glossary | Sable Peptides"
description: "Ion-exchange chromatography separates molecules based on their net charge using a stationary phase bearing charged groups. Cation exchangers retain positiv"
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Glossary

# Ion-exchange chromatography

Ion-exchange chromatography separates molecules based on their net charge using a stationary phase bearing charged groups. Cation exchangers retain positively charged species and anion exchangers retain negatively charged ones. It is used to purify peptides, to analyse charge variants and, in ion chromatography, to quantify counter-ions such as trifluoroacetate.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Ion_chromatography)

## Related terms

-   [Stationary phase](/glossary/stationary-phase)
-   [Ion chromatography](/glossary/ion-chromatography)

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