---
title: "Internal standard: research glossary | Sable Peptides"
description: "An internal standard is a known amount of a compound, different from the analyte but chemically similar, added to every sample and calibration standard. Ex"
canonical: https://www.sablepeptides.co.uk/glossary/internal-standard
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Internal standard

An internal standard is a known amount of a compound, different from the analyte but chemically similar, added to every sample and calibration standard. Expressing analyte response relative to it corrects for variability in sample preparation and instrument response. Stable isotope-labelled peptides are ideal internal standards in LC-MS.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Internal_standard)

## Related terms

-   [LC-MS](/glossary/lc-ms)

[Back to glossary A–Z](/glossary/terms)

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