---
title: "Hydrophobicity: research glossary | Sable Peptides"
description: "Hydrophobicity describes the tendency of a molecule or side chain to avoid water. Peptides rich in residues such as leucine, isoleucine, valine, phenylalan"
canonical: https://www.sablepeptides.co.uk/glossary/hydrophobicity
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Hydrophobicity

Hydrophobicity describes the tendency of a molecule or side chain to avoid water. Peptides rich in residues such as leucine, isoleucine, valine, phenylalanine and tryptophan are more hydrophobic, tend to elute later in reversed-phase HPLC and may need small amounts of organic solvent such as acetonitrile or DMSO to dissolve before dilution into aqueous buffer.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Hydrophobe)

## Related terms

-   [Acetonitrile](/glossary/acetonitrile)
-   [Buffer](/glossary/buffer)
-   [Valine](/glossary/valine)
-   [Leucine](/glossary/leucine)
-   [Isoleucine](/glossary/isoleucine)
-   [Phenylalanine](/glossary/phenylalanine)
-   [Tryptophan](/glossary/tryptophan)

[Back to glossary A–Z](/glossary/terms)

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