---
title: "Hydrolysis: research glossary | Sable Peptides"
description: "Hydrolysis is the cleavage of a chemical bond by reaction with water. Peptide bonds can be hydrolysed by strong acids, strong bases or protease enzymes, br"
canonical: https://www.sablepeptides.co.uk/glossary/hydrolysis
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Hydrolysis

Hydrolysis is the cleavage of a chemical bond by reaction with water. Peptide bonds can be hydrolysed by strong acids, strong bases or protease enzymes, breaking the chain into smaller fragments. Total acid hydrolysis, typically with 6 M hydrochloric acid at about 110 °C, is the first step of amino acid analysis used to quantify peptide content.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Hydrolysis)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Amino acid](/glossary/amino-acid)
-   [Cleavage](/glossary/cleavage)
-   [Amino acid analysis](/glossary/amino-acid-analysis)
-   [Protease](/glossary/protease)

[Back to glossary A–Z](/glossary/terms)

All Sable Peptides products are supplied for laboratory research use only. Not for consumption.