---
title: "HBTU: research glossary | Sable Peptides"
description: "HBTU is a widely used aminium-type coupling reagent for peptide synthesis, derived from HOBt. In the presence of a base such as DIPEA, it converts protecte"
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publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# HBTU

HBTU is a widely used aminium-type coupling reagent for peptide synthesis, derived from HOBt. In the presence of a base such as DIPEA, it converts protected amino acids into active esters that react with the resin-bound amine. It is cost-effective for routine Fmoc solid-phase synthesis.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/HBTU)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Coupling reagent](/glossary/coupling-reagent)
-   [Resin](/glossary/resin)
-   [DIPEA](/glossary/dipea)

[Back to glossary A–Z](/glossary/terms)

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