---
title: "Half-life: research glossary | Sable Peptides"
description: "Half-life is the time required for the quantity or concentration of a substance to fall to half its initial value. In peptide research, in vitro half-life"
canonical: https://www.sablepeptides.co.uk/glossary/half-life
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Half-life

Half-life is the time required for the quantity or concentration of a substance to fall to half its initial value. In peptide research, in vitro half-life in serum, plasma or buffer is measured to assess susceptibility to enzymatic and chemical degradation. Structural modifications can extend stability considerably.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Biological_half-life)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Buffer](/glossary/buffer)
-   [In vitro](/glossary/in-vitro)

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