---
title: "Glutamic acid: research glossary | Sable Peptides"
description: "Glutamic acid (three-letter code Glu, one-letter code E) is an acidic amino acid with a side-chain carboxyl group, negatively charged at physiological pH."
canonical: https://www.sablepeptides.co.uk/glossary/glutamic-acid
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Glutamic acid

Glutamic acid (three-letter code Glu, one-letter code E) is an acidic amino acid with a side-chain carboxyl group, negatively charged at physiological pH. It increases peptide solubility in neutral and basic buffers. Its side chain is commonly protected as a tert-butyl ester in Fmoc synthesis and can be used as an attachment point for linkers.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Glutamic_acid)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Amino acid](/glossary/amino-acid)
-   [One-letter code](/glossary/one-letter-code)
-   [Solubility](/glossary/solubility)

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