---
title: "Fmoc: research glossary | Sable Peptides"
description: "Fmoc (fluorenylmethyloxycarbonyl) is a base-labile protecting group used to block the amino group of amino acids during solid-phase peptide synthesis. It i"
canonical: https://www.sablepeptides.co.uk/glossary/fmoc
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Fmoc

Fmoc (fluorenylmethyloxycarbonyl) is a base-labile protecting group used to block the amino group of amino acids during solid-phase peptide synthesis. It is removed each cycle with a secondary amine, usually piperidine in DMF. Fmoc chemistry is paired with acid-labile side-chain protecting groups, which are removed during the final TFA cleavage step.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Fluorenylmethyloxycarbonyl_protecting_group)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Solid-phase peptide synthesis](/glossary/solid-phase-peptide-synthesis)
-   [Protecting group](/glossary/protecting-group)
-   [Cleavage](/glossary/cleavage)
-   [Piperidine](/glossary/piperidine)

[Back to glossary A–Z](/glossary/terms)

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