---
title: "Disulfide bond: research glossary | Sable Peptides"
description: "A disulfide bond is a covalent sulfur-sulfur link, typically formed by oxidation of the thiol groups of two cysteine residues. In peptides it creates cycli"
canonical: https://www.sablepeptides.co.uk/glossary/disulfide-bond
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Disulfide bond

A disulfide bond is a covalent sulfur-sulfur link, typically formed by oxidation of the thiol groups of two cysteine residues. In peptides it creates cyclic or bridged structures that constrain conformation. Forming a disulfide removes two hydrogen atoms, lowering the mass by about 2 Da, and the bond can be broken by reducing agents such as dithiothreitol.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Disulfide)

## Related terms

-   [Oxidation](/glossary/oxidation)
-   [Cysteine](/glossary/cysteine)
-   [Dithiothreitol](/glossary/dithiothreitol)

[Back to glossary A–Z](/glossary/terms)

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